3-Methylbenzene-1,2-dicarboxylic acid
5-iodo-2,4-dimethoxypyrimidine
CAS: 52522-99-3
Molecular Formula: C6H7IN2O2
3-Methylbenzene-1,2-dicarboxylic acid - Names and Identifiers
| Name | 5-iodo-2,4-dimethoxypyrimidine |
| Synonyms | 3-METHYLPHTHALIC ACID 2,3-Toluenedicarboxylic acid 5-Iodo-2,4-dimethoxypyrimidin 2,4-Dimethoxy-5-iodopyrimidine 5-iodo-2,4-dimethoxypyrimidine 5-IODO-2,4-DIMETHOXYPYRIMIDINE Pyrimidine, 5-iodo-2,4-dimethoxy- 3-Methylbenzene-1,2-dicarboxylic acid |
| CAS | 52522-99-3 |
| InChI | InChI=1/C9H8O4/c1-5-3-2-4-6(8(10)11)7(5)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13) |
3-Methylbenzene-1,2-dicarboxylic acid - Physico-chemical Properties
| Molecular Formula | C6H7IN2O2 |
| Molar Mass | 266.04 |
| Density | 1.822±0.06 g/cm3(Predicted) |
| Melting Point | 71-75 °C (lit.) |
| Boling Point | 328.7±52.0 °C(Predicted) |
| Flash Point | 195.3°C |
| Solubility | Chloroform; Dichloromethane |
| Vapor Presure | 2.55E-06mmHg at 25°C |
| Appearance | Solid |
| Color | Off-White |
| pKa | 1.33±0.29(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Sensitive | Light Sensitive |
| Refractive Index | 1.603 |
| MDL | MFCD00090865 |
3-Methylbenzene-1,2-dicarboxylic acid - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Class | IRRITANT, TOXIC |
3-Methylbenzene-1,2-dicarboxylic acid - Reference Information
| preparation | under nitrogen protection, 2, 4-dimethoxypyrimidine (1.4g,10mmol) is dissolved in tetrahydrofuran (14mL), cooled to about 0 ℃, and 1M magnesium dichloride (2,2,6,6-tetramethylpiperidine) lithium salt (11mL,11mmol) is added dropwise under stirring, continue stirring for 2 hours, then add iodine (2.79g,11mmol) under stirring, maintain low temperature reaction for 2 hours, naturally return to room temperature, continue stirring for 6 hours. The reaction solution is poured into ammonium chloride aqueous solution for quenching, ethyl acetate is extracted three times, combined, washed, dried and concentrated. After the obtained crude column chromatography, 2, 4-dimethoxy-5-iodopyrimidine (2.34g, yield 88%) was obtained. |
| Uses | 2,4-dimethoxy-5-iodopyrimidine is a nucleoside compound that can be used as a biochemical reagent. |
Last Update：2024-04-09 15:16:50
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